Description

The Allegro STR bioreactor family combines Pall’s bioprocess engineering expertise, cell culture know-how and our drive for quality into a series of single-use bioreactors that deliver consistent and scalable cell culture performance across the range. The Allegro STR bioreactor family has a direct bottom-driven impellor allowing power inputs up to 0.25 W/kg, resulting in high oxygen transfer rates and short mixing times.

Typical applications include:
– Suspension cell culture, using e.g. HEK293 cells, to produce viral vectors for gene therapy or vaccines
– Insect cell culture, using e.g. Sf9 cells, to produce baculovirus for gene therapy
– Suspension cell culture, using e.g. CHO cells, to produce monoclonal antibodies
– Adherent cell culture, using e.g. VERO on microcarriers, to produce viral vectors for gene therapy or vaccines

From the outset of the design, our technology placed strong emphasis toward providing a compact, ergonomic bioreactor design concept to maximize usability and process assurance, while maintaining optimal performance needed in a cell culture environment through several easy and intuitive operation features:

– The single bottom-mounted impeller design allows the biocontainer to be packed into a compact unit that can be placed directly into the hardware with minimal operator manipulation

– Installation and inflation of the biocontainer is achieved in < 30 minutes through a guided sequence via the Human Machine Interface (HMI)

– The low aspect ratio of the systems minimize the operations that have to be performed at height.

– Automatic biocontainer deflation speeds up turnaround time, minimizes operator activity and reduces the overall volume of waste for disposal